Plomin R
Center for Developmental and Health Genetics, College of Health and Human Development, Pennsylvania State University, University Park 16802.
Science. 1990 Apr 13;248(4952):183-8. doi: 10.1126/science.2183351.
Inheritance plays a major role in behavior as shown by selection and strain studies for animal behavior and by twin and adoption studies for human behavior. Unlike simple Mendelian characteristics, genetic variance for behavioral dimensions and disorders rarely accounts for more than half of the phenotypic variance, and multiple genes with small effects appear to be involved rather than one or two major genes. Genetic research on behavior will be transformed by techniques of molecular biology that can be used to identify DNA sequences responsible for behavioral variation. However, the importance of nongenetic factors and the multigenetic control of behavior require new strategies to detect DNA markers that account for small amounts of behavioral variation.
如动物行为的选择和品系研究以及人类行为的双胞胎和收养研究所示,遗传在行为中起着重要作用。与简单的孟德尔性状不同,行为维度和障碍的遗传方差很少占表型方差的一半以上,似乎涉及多个效应较小的基因,而不是一两个主要基因。行为的遗传研究将因分子生物学技术而发生变革,这些技术可用于识别导致行为变异的DNA序列。然而,非遗传因素的重要性以及行为的多基因控制需要新的策略来检测解释少量行为变异的DNA标记。