Aparisi T, Arborgh B, Ericsson J L
Virchows Arch A Pathol Anat Histol. 1979 Feb 9;381(2):159-78. doi: 10.1007/BF01257881.
Eleven benign giant cell tumors of bone were studied in the electron microscope, and the fine structural localization of acid phosphatase was elucidated. Three distinct cell types are always present in these tumors: stromal cells type 1; stromal cells type 2; and multinucleated giant cells. Small mononuclear cells may also occur, but are not likely to be actively participating in the neoplastic process. The range of variability in the fine structure of the different cell types constituting this tumor has been established. Variations in appearances include: a) presence of nuclear pseudoinclusions in stromal cells type 1 and multinucleated giant cells; b) aberrations in the structure of the rough surfaced endoplasmic reticulum in the same cell types; c) occurrence of ruffled borders, ectoplasmic layers and cytoplasmic labyrinths containing acid phosphatase in the giant cells. Some giant cells show evidence of marked phagocytic activity and contain large and numerous residual bodies carrying acid phosphatase. The significance of the interrelations between the different cell types are discussed and the possible role of stromal cells type 2 in immunological mechanisms directed against the tumor cells are mentioned.
对11例骨良性巨细胞瘤进行了电镜研究，阐明了酸性磷酸酶的精细结构定位。这些肿瘤中始终存在三种不同的细胞类型：1型基质细胞；2型基质细胞；以及多核巨细胞。也可能出现小单核细胞，但它们不太可能积极参与肿瘤形成过程。已确定构成该肿瘤的不同细胞类型在精细结构上的变异范围。外观变化包括：a）1型基质细胞和多核巨细胞中存在核假包涵体；b）相同细胞类型中粗面内质网结构异常；c）巨细胞中出现含酸性磷酸酶的皱襞缘、外质层和细胞质迷路。一些巨细胞显示出明显的吞噬活性证据，并含有大量携带酸性磷酸酶的残留小体。讨论了不同细胞类型之间相互关系的意义，并提及了2型基质细胞在针对肿瘤细胞的免疫机制中的可能作用。
