Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Exp Gerontol. 2011 Nov;46(11):953-7. doi: 10.1016/j.exger.2011.07.006. Epub 2011 Jul 28.
Serum biomarkers to identify susceptibility to disease in aged humans are well researched. On the other hand, our understanding of biomarkers in animal models of aging is limited. Hence, we applied a commercially available panel of 58 serum analytes to screen for possible biomarkers of aging in 4, 12, and 24 month old Brown Norway rats. We found that serum levels of 5 of the 58 analytes were significantly affected by age: C-reactive protein (CRP), myoglobin, macrophage derived chemokine-2 (MDC), fibroblast growth factor-basic, and vascular cell adhesion molecule-1. Among these analytes, CRP was the only one that increased with aging. The variability of CRP and MDC-2 was relatively low compared to the other analytes of the panel. It is concluded that CRP and possibly MDC-2 are candidates for biomarkers of aging in the BN rat.
用于鉴定老年人群疾病易感性的血清生物标志物已有大量研究。另一方面，我们对衰老动物模型中生物标志物的理解是有限的。因此，我们应用了一种商业化的 58 种血清分析物的检测试剂盒，来筛选 4、12 和 24 月龄的褐鼠中可能的衰老生物标志物。我们发现，58 种分析物中有 5 种的血清水平受年龄影响显著：C 反应蛋白（CRP）、肌红蛋白、巨噬细胞来源的趋化因子-2（MDC）、碱性成纤维细胞生长因子和血管细胞黏附分子-1。在这些分析物中，只有 CRP 随着衰老而增加。与检测试剂盒中的其他分析物相比，CRP 和 MDC-2 的变化相对较小。因此可以得出结论，CRP 和可能的 MDC-2 是 BN 大鼠衰老生物标志物的候选者。
