Endocrinology and Metabolism Division, Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan.
Diabetes Res Clin Pract. 2011 Nov;94(2):180-5. doi: 10.1016/j.diabres.2011.07.002. Epub 2011 Aug 10.
This study aimed to examine the associations of cognitive function with hippocampal and whole brain atrophies, age, education, and diabetes-related parameters in patients with type 2 diabetes. Sixty-one patients over 65 years of age with type 2 diabetes and 53 age- and sex-matched non-diabetic controls were enrolled. Hippocampal and whole brain atrophies were assessed by quantifying hippocampal and brain volumes by brain magnetic resonance imaging. Cognitive function was evaluated by Mini-Mental State Examination (MMSE) and the Revised Hasegawa Dementia Scale (HDS-R). Compared with the non-diabetic group, patients with type 2 diabetes showed significant increases in hippocampal and whole brain atrophies. The MMSE and HDS-R scores in type 2 diabetic patients showed significant negative correlations with age and significant positive correlations with years of education. These scores were also significantly negatively correlated with hippocampal atrophy, but not whole brain atrophy. Hippocampal atrophy in diabetic patients did not, however, correlate with age, years of education, or diabetes-related parameters. We showed hippocampal and whole brain atrophies to be more frequent in elderly patients with type 2 diabetes than in non-diabetic controls. Their cognitive functions were significantly and negatively associated with hippocampal atrophy.
本研究旨在探讨 2 型糖尿病患者认知功能与海马和全脑萎缩、年龄、教育程度以及与糖尿病相关参数的关系。共纳入 61 名年龄在 65 岁以上的 2 型糖尿病患者和 53 名年龄和性别匹配的非糖尿病对照组。通过脑磁共振成像定量评估海马和脑体积，评估海马和全脑萎缩。通过简易精神状态检查（MMSE）和修订后的长谷川痴呆量表（HDS-R）评估认知功能。与非糖尿病组相比，2 型糖尿病患者的海马和全脑萎缩明显增加。2 型糖尿病患者的 MMSE 和 HDS-R 评分与年龄呈显著负相关，与受教育年限呈显著正相关。这些评分也与海马萎缩显著负相关，但与全脑萎缩无关。然而，糖尿病患者的海马萎缩与年龄、受教育年限或与糖尿病相关的参数无关。我们发现，与非糖尿病对照组相比，老年 2 型糖尿病患者的海马和全脑萎缩更为常见。他们的认知功能与海马萎缩显著负相关。
