Yilmaz Ali Abbas, Can Ozlem Selvi, Oral Mehmet, Unal Necmettin, Ayyildiz Erol, Ilhan Osman, Tulunay Melek
Ankara University, Faculty of Medicine, Anaesthesiology and Intensive Care, Ibn-i Sina Hospital, 06100 Ankara, Turkey.
Transfus Apher Sci. 2011 Oct;45(2):161-6. doi: 10.1016/j.transci.2011.04.008. Epub 2011 Aug 10.
Therapeutic plasma exchange (TPE) is a blood purification method that effectively allows for the removal of waste substances by separating out plasma from other components of blood and the removed plasma is replaced with solutions such as albumin and/or plasma, or crystalloid/colloid solutions. Plasma exchange therapies are becoming increasingly essential, being used in daily practice in critical care settings for various indications, either as a first-line therapeutic intervention or as an adjunct to conventional therapies. This retrospective clinical study analyzes 10-year therapeutic plasma exchange activity experience in an 18-bed ICU at a tertiary care university hospital with a large, critically-ill patient population. Medical records of 1188 plasma exchange procedures on 329 patients with different diagnoses admitted from January 2000 to July 2010 were evaluated. The aim of the study was to determine the TPE indications and outcomes of the patients who underwent TPE in the ICU with conventional therapy. The secondary endpoints were to determine the differences between different patient groups (septic vs. non-septic indications) in terms of adverse events and procedural differences.
治疗性血浆置换（TPE）是一种血液净化方法，通过从血液的其他成分中分离出血浆，有效地去除废物，并用白蛋白和/或血浆等溶液或晶体/胶体溶液替代被去除的血浆。血浆置换疗法正变得越来越重要，在重症监护环境中用于各种适应症的日常实践中，既作为一线治疗干预措施，也作为传统疗法的辅助手段。这项回顾性临床研究分析了一所三级护理大学医院中拥有18张床位且重症患者众多的ICU十年的治疗性血浆置换活动经验。评估了2000年1月至2010年7月期间收治的329例不同诊断患者的1188次血浆置换程序的病历。该研究的目的是确定在ICU接受传统治疗的接受TPE患者的TPE适应症和结局。次要终点是确定不同患者组（脓毒症与非脓毒症适应症）在不良事件和程序差异方面的差异。
