Delmer A, Karmochkine M, Cadiou M, Gerhartz H, Zittoun R
Service d'Hématologie, Hôtel-Dieu, Paris, France.
Am J Hematol. 1990 May;34(1):73-4. doi: 10.1002/ajh.2830340117.
A 65-year-old woman with refractory anemia with excess of blasts received sequential courses of granulocyte-macrophage colony-stimulating factor therapy (GM-CSF) and low-dose cytosine arabinoside. Each course of GM-CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen.
一名65岁患有原始细胞过多的难治性贫血女性接受了粒细胞-巨噬细胞集落刺激因子疗法（GM-CSF）和小剂量阿糖胞苷的序贯疗程。GM-CSF的每个疗程均导致白细胞计数以及脾脏大小迅速大幅增加，氯化铟扫描提示脾脏存在髓外化生。这一观察结果表明，在某些患者中，脾脏对髓系生长因子刺激的粒细胞生成反应可能占主导。
