Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada.
J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):98-101. doi: 10.1136/jnnp-2011-300869. Epub 2011 Aug 11.
To examine how a cued change in motor plan influences Parkinson's disease (PD) patients with freezing of gait (FOG) (PD FOG; n=10), compared with those without FOG (PD non-FOG; n=10) and healthy controls (n=10).
Participants walked through a doorway in three experimental conditions: no cue; cue before gait initiation; and cue after gait initiation. The light cue was presented at the end of the pathway and signified that individuals must walk to the cue, turn around and return to starting position.
Step-to-step variability (a known precursor to FOG) revealed a significant main effect of group (F2,27=32.83, p<0.001), where PD FOG walked with greater step length variability than PD non-FOG and the control group. A significant interaction (F4,54=3.035, p=0.025) demonstrated that only the PD FOG group was most variable when the cue was present before gait initiation.
This study concludes that motor planning deficits affect gait, specifically in individuals who experience FOG. This may have important implications for the design of therapeutic interventions in PD FOG.
研究提示改变运动计划如何影响伴有冻结步态的帕金森病（PD）患者（PD FOG；n=10），并与无冻结步态的 PD 患者（PD 非 FOG；n=10）和健康对照组（n=10）进行比较。
参与者在三种实验条件下穿过门道：无提示；在步态启动前提示；在步态启动后提示。光提示出现在路径的尽头，意味着个体必须走到提示处，转身并返回起始位置。
步长变异性（已知的冻结步态前兆）显示出显著的组间效应（F2,27=32.83，p<0.001），其中 PD FOG 的步长变异性大于 PD 非 FOG 和对照组。显著的交互作用（F4,54=3.035，p=0.025）表明，只有 PD FOG 组在步态启动前存在提示时最具变异性。
本研究得出结论，运动计划缺陷会影响步态，特别是在经历冻结步态的个体中。这对于 PD FOG 的治疗干预设计可能具有重要意义。
