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甲型病毒性肝炎相关性急性胰腺炎和无结石性胆囊炎

[Acute pancreatitis and acalculous cholecystitis associated with viral hepatitis A].

作者信息

Arcana Ronald, Frisancho Oscar

机构信息

Departamento del Aparato Digestivo, Hospital Nacional Edgardo Rebagliati Martins, EsSALUD, Lima, Perú.

出版信息

Rev Gastroenterol Peru. 2011 Apr-Jun;31(2):178-82.

Abstract

We report the case of a 14 year-old male from Lima. He is a student with a history of bronchial asthma since age 4 receives conditional salbutamol, corticosteroids used for asthma attacks (a crisis in 2010, 1 month ago) Refuses surgery or transfusions. He presented with a two weeks for abdominal pain, nausea, fever, and jaundice. Epigastric pain is colicky and radiated back to righ upper quadrant, refers in addition to nausea and fever, for ten days notice jaundice of skin and sclera. On examen he was lucid, with jaundice of skin and mucous membranes. There was no palpable lymph nodes, abdomen with bowel sounds, soft, depressible, liver span of 15cm, positive Murphy, no peritonitis. The laboratory findings showed hemoglobin 13gr, MCV 90, platelets 461.000/mm3, WBC 4320/mm, lymphocytes 1700 (39%). total bilirubin: 8.8, B Direct: 7.6, ALT (alanine aminotransferase): 3016, AST (aspartate aminotransferase): 984, alkaline phosphatase: 250, albumin: 3.34gr%, globulin: 2.8, amylase: 589 (high serum amylase), TP: 17, INR: 1.6, VHA IgM positive. 89 mg glucose, urea 19 mg%, creatinine 0.5 mg Hemoglobin 13gr, MCV 90 Platelet 461000/mm3, WBC 4320/mm, Lymphocytes 1700 (39%). The nuclear magnetic resonance showed hepatomegaly associated with thickening of gallbladder wall without stones up to 11mm inside. No bile duct dilatation, bile duct 4mm, pancreas increased prevalence of body size. Mild splenomegaly and free fluid in the space of Morrison and right flank. Abdominal ultrasound revealed a gallbladder wall thickness (11mm), without stones in his light. Pancreas to increase volume with peripancreatic fluid free perivesicular with a volume of 430 cc. Findings consistent with acute acalculous cholecystitis and acute pancreatitis. CT-scan showed enlarged pancreas with predominance of body and tail with peripancreatic edema; the gallbladder was thickening. We report this case because the extrahepatic manifestations of viral hepatitis A infection are uncommon, specially the associated with acute acalculous cholecystitis and acute pancreatitis simultaneous.

摘要

我们报告了一名来自利马的14岁男性病例。他是一名学生,自4岁起有支气管哮喘病史,接受过沙丁胺醇治疗,曾在2010年(1个月前)因哮喘发作使用过皮质类固醇,拒绝手术或输血。他因腹痛、恶心、发热和黄疸症状持续两周前来就诊。上腹部疼痛呈绞痛状,放射至右上腹,伴有恶心和发热,10天前出现皮肤和巩膜黄疸。检查时他神志清醒,有皮肤和黏膜黄疸。未触及可触及的淋巴结,腹部有肠鸣音,柔软,可压陷,肝脏跨度为15厘米,墨菲氏征阳性,无腹膜炎。实验室检查结果显示血红蛋白13克,平均红细胞体积90,血小板461,000/mm³,白细胞4320/mm,淋巴细胞1700(39%)。总胆红素:8.8,直接胆红素:7.6,谷丙转氨酶(丙氨酸氨基转移酶):3016,谷草转氨酶(天冬氨酸氨基转移酶):984,碱性磷酸酶:250,白蛋白:3.34克%,球蛋白:2.8,淀粉酶:589(血清淀粉酶高),总蛋白:17,国际标准化比值:1.6,甲型肝炎病毒IgM阳性。血糖89毫克,尿素19毫克%,肌酐0.5毫克,血红蛋白13克(原文重复),平均红细胞体积90,血小板461,000/mm³,白细胞4320/mm,淋巴细胞1700(39%)。核磁共振显示肝脏肿大,胆囊壁增厚,无结石,胆囊内厚度达11毫米。无胆管扩张,胆管4毫米,胰腺体部体积增大。轻度脾肿大,莫里森间隙和右胁腹有游离液体。腹部超声显示胆囊壁厚度(11毫米),胆囊内无结石。胰腺体积增大,胰周有430立方厘米的无液性囊泡。检查结果符合急性非结石性胆囊炎和急性胰腺炎。CT扫描显示胰腺肿大,以体部和尾部为主,伴有胰周水肿;胆囊壁增厚。我们报告此病例是因为甲型病毒性肝炎感染的肝外表现并不常见,特别是同时伴有急性非结石性胆囊炎和急性胰腺炎。

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