MRI 检测鼻咽癌颅底侵犯的分级及其预后价值。
Grading of MRI-detected skull-base invasion in nasopharyngeal carcinoma and its prognostic value.
机构信息
State Key Laboratory of Oncology in Southern China, Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
出版信息
Head Neck. 2011 Sep;33(9):1309-14. doi: 10.1002/hed.21606. Epub 2010 Nov 10.
BACKGROUND
Our aim was to grade MRI-detected skull-base invasion in nasopharyngeal carcinoma and evaluate the prognostic value of the grading.
METHODS
The MRI scans and medical records of 924 patients with histologically diagnosed nondisseminated nasopharyngeal carcinoma were reviewed retrospectively.
RESULTS
MRI-detected skull-base invasion was not found to be an independent prognostic factor for overall survival, distant metastasis-free survival, or local relapse-free survival (p > .05 for all). Grading of skull-base erosion according to the site of invasion was found to be an independent prognostic factor for both overall survival (p = .003 and p = .006, respectively) and distant metastasis-free survival (p = .001 for both) in the 512 patients with skull-base invasions and 315 patients with T3 disease.
CONCLUSIONS
MRI-detected skull-base invasion is not an independent prognostic factor for nasopharyngeal carcinoma. However, grading according to the site of invasion as either low grade or severe has prognostic value.
背景
我们的目的是对鼻咽癌的 MRI 检测到的颅底侵犯进行分级，并评估分级的预后价值。
方法
回顾性分析了 924 例经组织学诊断为非播散性鼻咽癌患者的 MRI 扫描和病历。
结果
MRI 检测到的颅底侵犯不是总生存、远处无转移生存或局部无复发生存的独立预后因素（所有 p 值均>.05）。根据侵犯部位对颅底侵蚀进行分级，在 512 例颅底侵犯和 315 例 T3 疾病患者中，对于总生存（p =.003 和 p =.006）和远处无转移生存（两者均为 p =.001），均为独立的预后因素。
结论
MRI 检测到的颅底侵犯不是鼻咽癌的独立预后因素。然而，根据侵犯部位进行分级为低级别或严重级别具有预后价值。
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