Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
Radiat Oncol. 2019 Jan 17;14(1):10. doi: 10.1186/s13014-019-1214-3.
The aim of this study is to evaluate the prognostic value of grading MRI-detected skull-base invasion in nasopharyngeal carcinoma (NPC) with skull-base invasion after intensity-modulated radiotherapy (IMRT).
This study is a retrospective chart review of 469 non-metastatic NPC patients with skull-base invasion. Patients were classified as extensive skull-base invasion (ESBI) group and limited skull-base invasion (LSBI) group.
Multivariate analysis showed that the skull-base invasion (LSBI vs. ESBI) was an independent prognostic predictor of progression free survival (PFS). The estimated 5-year local failure free survival (LFFS), distant metastasis free survival (DMFS), PFS, and overall survival (OS) rates for patients in the T3-LSBI and T3-ESBI group were 92.9% versus 93.5, 89.8% versus 86.1, 81.6% versus 76.4, and 93.5% versus 86.3%, respectively (P > 0.05).
Grading of MRI-detected skull-base invasion is an independent prognostic factor of NPC with skull-base invasion. It is scientific and reasonable for skull-base invasion as a single entity to be classified as T3 classification.
本研究旨在评估 MRI 检测到的颅底侵犯在调强放疗（IMRT）后伴颅底侵犯的鼻咽癌（NPC）中的预后价值。
本研究是对 469 例无远处转移的颅底侵犯 NPC 患者进行的回顾性图表分析。患者分为广泛颅底侵犯（ESBI）组和局限颅底侵犯（LSBI）组。
多因素分析显示，颅底侵犯（LSBI 与 ESBI）是无进展生存（PFS）的独立预后预测因子。T3-LSBI 和 T3-ESBI 组患者的 5 年局部无失败生存率（LFFS）、远处无转移生存率（DMFS）、PFS 和总生存率（OS）分别为 92.9%比 93.5%、89.8%比 86.1%、81.6%比 76.4%和 93.5%比 86.3%（P>0.05）。
MRI 检测到的颅底侵犯分级是颅底侵犯 NPC 的独立预后因素。将颅底侵犯作为单一实体进行 T3 分类是科学合理的。
