Labelle Amber L, Hamor Ralph E, Townsend Wendy M, Mitchell Mark A, Zarfoss Mitzi K, Breaux Carrie B, Thomasy Sara M, Hall Tiffany
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61802, USA.
J Am Vet Med Assoc. 2011 Aug 15;239(4):486-92. doi: 10.2460/javma.239.4.486.
To determine types and frequency of ophthalmic lesions detected in neonatal foals evaluated for nonophthalmic disease at 3 veterinary referral hospitals and to investigate associations between systemic and ophthalmic diseases in these foals.
Prospective cross-sectional study.
70 foals < 30 days old.
Complete ophthalmic examinations were performed. Signalment, clinical signs, mentation during ophthalmic examination, results of clinicopathologic tests, and diagnosis of systemic disease were recorded. Descriptive data analysis including a χ(2) test for associations was performed.
Most foals (39/70 [55.7%]) with systemic disease had ≥ 1 ophthalmic lesion detected. Of the 39 foals with ophthalmic disease, 24 (61.5%) had potentially vision-threatening lesions. Clinically important abnormalities included conjunctival hyperemia or episcleral injection (30/70 [42.9%]), uveitis (18/70 [25.7%]), ulcerative keratitis (13/70 [18.6%]), nonulcerative keratitis (10/70 [14.3%]), entropion (8/70 [11.4%]), retinal hemorrhage (8/70 [11.4%]), and cataract (6/70 [8.6%]). Foals with sepsis were significantly more likely to have uveitis than were those without sepsis. Foals with sepsis and uveitis were also significantly less likely to survive to discharge than were foals that had sepsis without uveitis. Acquired ophthalmic disease (detected in 37/70 [52.9%] foals) was significantly more common than congenital ophthalmic disease (detected in 9/70 [12.9%]).
Ophthalmic lesions were detected in 55.7% of neonatal foals with systemic disease. Acquired ophthalmic disease was more commonly detected than congenital ophthalmic disease. Foals with sepsis were more likely to have uveitis than were foals without sepsis. A complete ophthalmic examination is indicated in neonatal foals evaluated for systemic disease.
确定在3家兽医转诊医院对患有非眼科疾病的新生驹进行评估时检测到的眼科病变类型和频率，并调查这些驹的全身性疾病与眼科疾病之间的关联。
前瞻性横断面研究。
70匹年龄小于30日龄的驹。
进行全面的眼科检查。记录畜主信息、临床症状、眼科检查时的精神状态、临床病理检查结果以及全身性疾病的诊断。进行描述性数据分析，包括用于关联分析的χ²检验。
大多数患有全身性疾病的驹（39/70 [55.7%]）检测到≥1处眼科病变。在39匹患有眼科疾病的驹中，24匹（61.5%）有潜在威胁视力的病变。具有临床重要意义的异常包括结膜充血或巩膜表层血管充血（30/70 [42.9%]）、葡萄膜炎（18/70 [25.7%]）、溃疡性角膜炎（13/70 [18.6%]）、非溃疡性角膜炎（10/70 [14.3%]）、睑内翻（8/70 [11.4%]）、视网膜出血（8/70 [11.4%]）和白内障（6/70 [8.6%]）。患有败血症的驹比未患败血症的驹更易患葡萄膜炎。患有败血症和葡萄膜炎的驹比患有败血症但无葡萄膜炎的驹存活至出院的可能性也显著降低。后天性眼科疾病（在37/70 [52.9%]的驹中检测到）比先天性眼科疾病（在9/70 [12.9%]的驹中检测到）更为常见。
在55.7%患有全身性疾病的新生驹中检测到眼科病变。后天性眼科疾病比先天性眼科疾病更常被检测到。患有败血症的驹比未患败血症的驹更易患葡萄膜炎。对于评估全身性疾病的新生驹，建议进行全面的眼科检查。
