Sancho A, Pastor M C, Cañas L, Morales Indiano C, Ardèvol M, Aguerrevere S, Juega J, Romero R, Lauzurica R
Department of Biochemistry, Hospital Universitari Germans Trias I Pujol, Barcelona, Spain.
Transplant Proc. 2011 Jul-Aug;43(6):2196-8. doi: 10.1016/j.transproceed.2011.05.019.
Anemia frequently occurs after kidney transplantation, its origin is multifactorial. The objective of this study was to evaluate the frequency of anemia among kidney transplantation patients at 3 months after transplantation and its relationship to inflammatory, oxidative, and nutritional states. Furthermore, we determined serum prohepcidin, a precursor of hepcidin, the main hormone implicated in iron metabolism.
We performed a transverse retrospective study in 130 patients who underwent kidney transplantation, including 89 men and 41 women. Patients were randomized according to the presence or absence of anemia at 3 months. The patients' inflammatory, oxidative, and nutritional states were evaluated as well as renal function and serum prohepcidin at 3 months.
Twenty-four percent of the patients developed anemia at 3 months after transplantation. These patients presented with a greater inflammatory state, a poor nutritional status, and poor renal function. Serum prohepcidin was significantly lower compared with the transplantation patients who did not show anemia.
Serum prohepcidin was significantly higher among kidney transplantation patients who did not develop anemia. The inflammatory state may be a determinant of the response to treatment with erythropoiesis-stimulating agents in anemic kidney transplant recipients.
贫血在肾移植后经常发生，其病因是多因素的。本研究的目的是评估肾移植患者移植后3个月时贫血的发生率及其与炎症、氧化和营养状态的关系。此外，我们测定了血清前铁调素，铁调素的前体，铁代谢中主要涉及的激素。
我们对130例接受肾移植的患者进行了一项横向回顾性研究，其中包括89名男性和41名女性。根据移植后3个月时是否存在贫血将患者随机分组。评估了患者的炎症、氧化和营养状态以及3个月时的肾功能和血清前铁调素。
24%的患者在移植后3个月时发生贫血。这些患者表现出更高的炎症状态、较差的营养状况和较差的肾功能。与未出现贫血的移植患者相比，血清前铁调素显著降低。
未发生贫血的肾移植患者血清前铁调素显著升高。炎症状态可能是贫血肾移植受者对促红细胞生成素治疗反应的一个决定因素。
