中央桥脑和脑桥外髓鞘溶解症：肝移植术后一种罕见的致命并发症。

Central pontine and extrapontine myelinolysis: a rare and fatal complication after liver transplantation.

作者信息

Cascales Campos P, Ramirez P, Gonzalez R, Pons J A, Miras M, Sanchez Bueno F, Robles R, Parrilla P

机构信息

Liver Transplant Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.

出版信息

Transplant Proc. 2011 Jul-Aug;43(6):2237-8. doi: 10.1016/j.transproceed.2011.06.052.

DOI:10.1016/j.transproceed.2011.06.052

PMID:21839243

Abstract

Central pontine myelinolysis (CPM) may be more prevalent after liver transplantation (OLT). Central pontine and extrapontine myelinolysis (CPEM) is rare. The occurence of CPM may be associated with hyponatremia, a rapid rise in serum sodium concentrations, postoperatively increased plasma osmolality, and the duration of the operation. Only 1 patient had abnormal sodium levels before LT. No abnormalities were detected in immunosuppressive drug blood levels. The aim of this paper was to report our experience with CPEM among LT patients.

摘要

肝移植（OLT）后，中央桥脑髓鞘溶解症（CPM）可能更为常见。中央桥脑和脑桥外髓鞘溶解症（CPEM）则较为罕见。CPM的发生可能与低钠血症、血清钠浓度快速上升、术后血浆渗透压升高以及手术持续时间有关。肝移植前只有1例患者钠水平异常。免疫抑制药物血药浓度未检测到异常。本文旨在报告我们在肝移植患者中治疗CPEM的经验。