Office of Population Research, Princeton University, Princeton, NJ 08544, USA.
Atherosclerosis. 2011 Nov;219(1):349-54. doi: 10.1016/j.atherosclerosis.2011.07.100. Epub 2011 Jul 27.
Polymorphisms of the apolipoprotein E gene (ApoE) have been associated with health and longevity. Numerous studies have linked ApoE to health outcomes including cardiovascular disease and mortality, but far fewer studies have examined the relationship of ApoE to other biological markers of health. This study investigates the relationship between ApoE and mortality, as well as ApoE and a set of biomarkers related to cardiovascular and immune function, in a population-based sample of Taiwanese adults ages 54+. ApoE £2 carriers were less likely to have at-risk levels of high-density lipoprotein (HDL-C) and total cholesterol (total-C) than non-carriers (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.25-0.83 and OR 0.45, 95% CI 0.29-0.71, respectively). ApoE £4 carriers were less likely to have elevated levels of C-reactive protein (CRP) than non-carriers (OR 0.62, 95% CI 0.39-0.96). ApoE genotype was not, however, associated with mortality after 8 years of follow-up. Our findings confirm the association between ApoE £2and cholesterol levels, suggesting a potential protective effect of ApoE £2 on blood lipids. They also contribute to reports on the relationship between ApoE £4 carrier status and lower CRP levels.
载脂蛋白 E 基因（ApoE）的多态性与健康和长寿有关。许多研究将 ApoE 与包括心血管疾病和死亡率在内的健康结果联系起来，但很少有研究检查 ApoE 与其他健康生物标志物的关系。本研究在一个基于人群的台湾成年人样本中调查了 ApoE 与死亡率以及 ApoE 与一组与心血管和免疫功能相关的生物标志物之间的关系，这些成年人年龄在 54 岁以上。与非携带者相比，ApoE £2 携带者高密度脂蛋白（HDL-C）和总胆固醇（总-C）的高危水平的可能性较小（比值比 [OR] 0.45，95%置信区间 [CI] 0.25-0.83 和 OR 0.45，95% CI 0.29-0.71）。与非携带者相比，ApoE £4 携带者的 C 反应蛋白（CRP）水平升高的可能性较小（OR 0.62，95% CI 0.39-0.96）。然而，ApoE 基因型与 8 年随访后的死亡率无关。我们的发现证实了 ApoE £2 与胆固醇水平之间的关联，表明 ApoE £2 对血脂可能具有保护作用。它们还为 ApoE £4 携带者状态与 CRP 水平降低之间的关系报告做出了贡献。
