Biophys Chem. 2011 Nov;159(1):1-5. doi: 10.1016/j.bpc.2011.07.002. Epub 2011 Jul 21.
In 2011, the Gibbs Conference on Biothermodynamics will celebrate its 25th anniversary. Since the inaugural meeting in 1987, it has brought together laboratories that lived, breathed and argued about the molecular logic of macromolecular machines. The participants have a deep commitment to understanding the nature of physico-chemical forces that govern regulation of biological systems, and share a passion for applying linkage theory. The collective goal is to understand how ligand binding, subunit assembly and conformational change drive what we observe as physiological processes such as regulated transport, enzyme cascades, gene regulation, membrane permeability, viral infection, intracellular trafficking and folding of macromolecules. In this special issue, articles by former organizers of the Gibbs Conference showcase the current breadth and depth of the field of biothermodynamics, and how thoroughly it is integrated with the study of macromolecular structures, computational modeling and physiological studies of human health and disease.
2011 年，吉布斯生物热力学会议将迎来其 25 周年庆典。自 1987 年首次会议以来，它汇聚了众多实验室，这些实验室专注于研究生物大分子机器的分子逻辑。与会者都致力于深入理解调控生物系统的物理化学力的本质，并热衷于应用连锁理论。其共同目标是了解配体结合、亚基组装和构象变化如何驱动我们所观察到的生理过程，如调节运输、酶级联反应、基因调控、膜通透性、病毒感染、细胞内运输以及生物大分子的折叠等。在本期特刊中，吉布斯会议的前任组织者撰文展示了生物热力学领域当前的广度和深度，以及它与生物大分子结构研究、计算建模以及人类健康和疾病的生理学研究是如何紧密结合的。
