Christine M. Kleinert Institute for Hand and Micro Surgery, Louisville, KY 40202, USA.
Med Hypotheses. 2011 Oct;77(4):696-7. doi: 10.1016/j.mehy.2011.07.020. Epub 2011 Aug 12.
Fluoroquinolones are broad-spectrum antibacterial agents. Reports of Achilles tendon rupture as a possible side effect of the quinolones have been previously presented but mechanism of the side effect of the medication is still unknown. Tendon rupture in the forearm associated with fluoroquinolone use has not been reported. We present a patient who underwent levofloxacin treatment for skin infections and subsequently developed left small finger flexor digitorum profundus rupture. We propose that this rupture may be related to the side effect of the medication. If it is, clinicians have to be aware of possible tendon ruptures in the upper extremity due to side effects of quinolones and patients have to be informed about it.
氟喹诺酮类药物是一种广谱抗菌药物。已有报道称，此类药物可能会导致跟腱断裂，但该药物的副作用机制尚不清楚。氟喹诺酮类药物引起的前臂肌腱断裂尚未见报道。我们报告了一例患者，因皮肤感染接受左氧氟沙星治疗，随后出现左手小指屈指深肌断裂。我们推测这种断裂可能与药物的副作用有关。如果是这样，临床医生必须意识到由于喹诺酮类药物的副作用，上肢可能会发生肌腱断裂，并且必须告知患者。
