Plantamura J, Dorandeu F, Burnat P, Renard C
Département contrôle analytique, pharmacie centrale des armées, Fleury-les-Aubrais cedex, France.
Ann Pharm Fr. 2011 Jul;69(4):196-200. doi: 10.1016/j.pharma.2011.05.002. Epub 2011 Jul 20.
Arsines family includes many compounds with various toxicities. Arsenic trihydride or arsine is the most toxic form of arsenic. Powerful haemolytic gas, it has never been used as a chemical weapon because its toxicity is not immediate and it is non persistent. However, cases of industrial poisoning with arsine are still identified in spite of a strict regulation at work. It is also identified as a potential toxic of chemical terrorism. This agent, of which the mechanism of action is still not well defined, is badly recognized because of intoxications rarity. However, fast detection means are available. Health professionals and especially those who are involved in piratox plan need to learn to recognize arsine intoxication (hematuria, oliguria, haemolytic anemia) in order to provide early, specific treatment and avoid damages.
砷化氢类包括许多具有不同毒性的化合物。砷化三氢或砷化氢是砷的毒性最强的形式。它是一种强大的溶血气体，由于其毒性不是即时性的且无持久性，所以从未被用作化学武器。然而，尽管工作场所实施了严格监管，仍有砷化氢导致工业中毒的案例被发现。它也被认定为化学恐怖主义的潜在毒物。这种作用机制仍未明确的物质，由于中毒案例罕见而未得到充分认识。不过，已有快速检测手段。卫生专业人员，尤其是参与中毒防治计划的人员，需要学会识别砷化氢中毒（血尿、少尿、溶血性贫血），以便尽早提供特效治疗并避免损害。
