Sekkach Y, Hammi S, Elqatni M, Fatihi J, Elomri N, Mekouar F, Badaoui M, Jira M, Smaali J, El Khattabi A, Amezyane T, Abouzahir A, Ghafir D
Département de médecine interne B, hôpital militaire d'instruction, Med-V, Rabat, Maroc.
Ann Pharm Fr. 2011 Jul;69(4):205-8. doi: 10.1016/j.pharma.2011.06.002. Epub 2011 Jul 19.
Autoimmune hemolytic anemia with cold autoantibodies or cold agglutinin disease is a rare chronic disorder in which no treatment has, until now, evidence of its effectiveness.
We report a patient who successfully responded to rituximab for a cold agglutinin disease refractory to conventional therapy with very good tolerance and a complete remission.
There are only few observations that have been reported in the literature regarding the efficacity of rituximab in the treatment of cold agglutinin disease. This promising therapy could, in the future, constitute a real alternative.
伴有冷自身抗体的自身免疫性溶血性贫血或冷凝集素病是一种罕见的慢性疾病,迄今为止尚无治疗有效的证据。
我们报告一例对传统治疗无效的冷凝集素病患者,该患者使用利妥昔单抗治疗后取得成功,耐受性良好且完全缓解。
关于利妥昔单抗治疗冷凝集素病的疗效,文献中仅有少数报道。这种有前景的治疗方法未来可能成为一种切实可行的替代方案。