Nasyrov Sh N, Shvarts G Ia, Kukes V G, Faermark I F, Siubaev R D
Farmakol Toksikol. 1990 Jan-Feb;53(1):32-5.
Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil.
硝苯地平和维拉帕米（口服10毫克/千克）被发现可使自发性高血压大鼠的肾素活性显著增加，血浆中醛固酮和离子钙水平降低。预先给予高渗氯化钠溶液可降低肾素活性、离子钙和醛固酮水平，这有助于增强钙拮抗剂的降压作用。已证实，硝苯地平在对血流动力学参数、肾素 - 血管紧张素系统状况以及血浆离子钙水平的影响方面优于维拉帕米。
