[The use of the antipyrine test for studying microsomal drug oxidation].
作者信息
Viktorov A P, Rybak A T
出版信息
Farmakol Toksikol. 1990 Jan-Feb;53(1):74-7.
PMID:2184052
Abstract
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors and inhibitors on the liver microsomal enzyme activity. The research methods are described and the data on the effects of different environmental factors on antipyrine metabolism are presented. The peculiarities of using the drug as a model for studying the effects of different environmental factors on the drug metabolism are formulated.
摘要
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