Department of Pathology, S. Cuore Don Calabria Negrar 37024, Italy.
Hum Pathol. 2012 Mar;43(3):446-50. doi: 10.1016/j.humpath.2011.05.015. Epub 2011 Aug 15.
In this report, we describe a case of hitherto unreported primary retroperitoneal acinar cell cystadenoma that morphologically and immunophenotypically resembled pancreatic acinar cell cystadenoma. Pancreatic acinar cell cystadenoma is a very uncommon benign lesion characterized by acinar cell differentiation, the evidence of pancreatic exocrine enzyme production, and the absence of cellular atypia. Our case occurred in a 55-year-old woman presenting a 10-cm multilocular cystic lesion in the retroperitoneum thought to be a mucinous cystic neoplasm. At laparotomy, the cystic mass, which showed no connection with any organ, was completely resected with a clinical diagnosis of cystic lymphangioma. The diagnosis of retroperitoneal acinar cell cystadenoma was based on the recognition of morphological acinar differentiation, the immunohistochemical demonstration of the acinar marker trypsin, and the absence of cellular atypia. These peculiar features can be used in the differential diagnosis with all the other cystic lesions of the retroperitoneum.
在本报告中，我们描述了一例迄今未报道的原发性腹膜后腺泡细胞囊腺瘤，其形态学和免疫表型与胰腺腺泡细胞囊腺瘤相似。胰腺腺泡细胞囊腺瘤是一种非常罕见的良性病变，其特征为腺泡细胞分化、胰腺外分泌酶产生的证据以及细胞异型性缺失。我们的病例发生在一位 55 岁的女性，其腹膜后出现 10cm 多房囊性病变，考虑为黏液性囊腺瘤。剖腹探查时，囊性肿块与任何器官均无联系，临床诊断为囊性淋巴管瘤，故完整切除。腹膜后腺泡细胞囊腺瘤的诊断基于对形态学腺泡分化的识别、腺泡标志物胰蛋白酶的免疫组织化学显示以及细胞异型性缺失。这些特殊特征可用于与腹膜后所有其他囊性病变的鉴别诊断。
