Blichert-Toft M, Christiansen C, Engquist A, Kehlet H, Lindholm J, Hummer L, Dinesen B
Acta Anaesthesiol Scand. 1979 Feb;23(1):103-6. doi: 10.1111/j.1399-6576.1979.tb01428.x.
The hypothalamic-pituitary-adrenocortical (HPA) responses to the hypoglycaemic stimulus and to operation (laparotomy) are compared. The studies were carried out in eight patients who were subjected to insulin-induced hypoglycaemia on the day before elective abdominal surgery. Plasma corticotrophin (ACTH) and plasma cortisol concentration increases were virtually indentical during the two procedures, which suggests that hypoglycaemia and surgical trauma are comparable stress factors and that the hypoglycaemia test is reliable in predicting the HPA responses to major surgical trauma.
比较了下丘脑 - 垂体 - 肾上腺皮质（HPA）对低血糖刺激和手术（剖腹术）的反应。研究在八名择期腹部手术前一天接受胰岛素诱导低血糖的患者中进行。在这两种操作过程中，血浆促肾上腺皮质激素（ACTH）和血浆皮质醇浓度的增加几乎相同，这表明低血糖和手术创伤是相当的应激因素，并且低血糖测试在预测HPA对重大手术创伤的反应方面是可靠的。
