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围手术期医学中的心脏生物标志物:对非心脏手术患者的意义

[Cardiac biomarkers in perioperative medicine : significance for noncardiac surgery patients].

作者信息

Schlitt A, Reindl I, Ebelt H, Buerke M, Werdan K

机构信息

Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum, Martin Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.

出版信息

Anaesthesist. 2011 Aug;60(8):709-16. doi: 10.1007/s00101-011-1928-6.

Abstract

Perioperative detection of cardiac biomarkers may help to identify patients at risk. Whether detection of these markers will be recommended in the preoperative setting for patients with cardiac diseases in the future has to be discussed as large prospective trials on this topic are missing. For preoperative evaluation of cardiac insufficiency quantification of brain natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) are useful markers. Troponin is the marker of choice for detection of myocardial ischemia/infarction in the postoperative setting. In unstable patients coronary angiography and/or percutaneous coronary intervention (PCI) are indicated. However, in stable patients the decision for coronary angiography and/or PCI has to be made in each patient individually after interdisciplinary discussion between anesthesiologists, cardiologists and surgeons.

摘要

围手术期检测心脏生物标志物可能有助于识别有风险的患者。由于缺乏关于这一主题的大型前瞻性试验,未来是否会建议在术前对心脏病患者进行这些标志物的检测还有待讨论。对于心脏功能不全的术前评估,脑钠肽(BNP)和氨基末端脑钠肽前体(NT-proBNP)的定量是有用的标志物。肌钙蛋白是术后检测心肌缺血/梗死的首选标志物。对于不稳定患者,建议进行冠状动脉造影和/或经皮冠状动脉介入治疗(PCI)。然而,对于稳定患者,在麻醉医生、心脏病专家和外科医生进行多学科讨论后,必须为每个患者单独做出冠状动脉造影和/或PCI的决定。

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