Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cell Host Microbe. 2011 Aug 18;10(2):92-3. doi: 10.1016/j.chom.2011.07.008.
The identity of the receptors that mediate alphavirus entry into host cells has been elusive. In this issue of Cell Host & Microbe, Rose et al. (2011) use a Drosophila RNAi screen to identify NRAMP, an iron transporter with 12 transmembrane domains, as a receptor for Sindbis virus in both insect and mammalian cells.
介导甲病毒进入宿主细胞的受体一直难以确定。在本期《细胞宿主与微生物》中，Rose 等人（2011）利用果蝇 RNAi 筛选，鉴定出 12 个跨膜结构域的铁转运蛋白 NRAMP 为昆虫和哺乳动物细胞中辛德毕斯病毒的受体。
