The State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People's Republic of China.
Fertil Steril. 2011 Oct;96(4):905-11. doi: 10.1016/j.fertnstert.2011.07.1102. Epub 2011 Aug 16.
To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH).
Meta-analysis.
University hospital.
PATIENT(S): Patients undergoing IVF.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Poor ovarian response in controlled ovarian hyperstimulation (COH).
RESULT(S): Fifteen studies on serum inhibin B and 12 studies on AMH were selected for meta-analysis. Both basal and stimulated inhibin B levels were statistically significantly lower in poor ovarian responders than in controls. The estimated summary receiver operating characteristic (ROC) curves suggested that stimulated inhibin B was more accurate than basal inhibin B and AMH in the prediction of poor ovarian response.
CONCLUSION(S): Both basal and stimulated serum inhibin B levels are lower in poor responders than in controls. Compared with AMH, stimulated inhibin B is a more accurate predictor of ovarian response in patients undergoing IVF, making it a potentially useful tool in future IVF practice.
评估血清抑制素 B 作为体外受精/胞浆内单精子注射（IVF-ICSI）患者卵巢反应不良的预测指标，并与抗苗勒管激素（AMH）的表现进行比较。
荟萃分析。
大学医院。
接受 IVF 的患者。
无。
控制性卵巢超刺激（COH）中的卵巢反应不良。
选择了 15 项关于血清抑制素 B 的研究和 12 项关于 AMH 的研究进行荟萃分析。基础和刺激后的抑制素 B 水平在卵巢反应不良者中明显低于对照组。估计的综合接收者操作特征（ROC）曲线表明，在预测卵巢反应不良方面，刺激后的抑制素 B 比基础抑制素 B 和 AMH 更准确。
基础和刺激后的血清抑制素 B 水平在卵巢反应不良者中均低于对照组。与 AMH 相比，刺激后的抑制素 B 是预测 IVF 患者卵巢反应的更准确指标，因此可能成为未来 IVF 实践中的有用工具。
