Department of Poultry Science, The University of Georgia, Athens, GA 30602, USA.
Poult Sci. 2011 Sep;90(9):1967-74. doi: 10.3382/ps.2010-01240.
Fluoride has been shown to have varying degrees of beneficial effects on bone mineralization and bone strength, despite its toxic effects on growth and leg disorders. Some studies have demonstrated an increase in bone ash resulting from F supplementation. The purpose of the present study was to determine whether low levels of dietary F would have any beneficial effect on the bone strength and leg disorders of young chicks fed P-deficient diets. Effects on BW and feed efficiency were also observed to monitor for F toxicity. One-day-old straight-run Cobb × Cobb broiler chicks were weighed, randomly allocated to treatment groups, housed in electrically heated wire-floored battery brooders, and provided with water and feed for ad libitum consumption. Phosphorus-deficient diets were formulated to induce P rickets with 2 different P sources. Treatment 1 contained feed grade dicalcium phosphate to simulate a commercial diet. Treatment 2 contained purified dicalcium phosphate to represent a diet with minimal F (~0.46 mg/kg). Treatments 3 and 4 used purified dicalcium phosphate as the P source and contained 10 and 20 mg/kg of F from NaF, respectively. Four more treatments were added for experiment 2. Treatments 5, 6, 7, and 8 used purified dicalcium phosphate as the P source and contained 30, 40, 50, and 60 mg/kg of F from NaF, respectively. The analyzed F values in the diet were lower than the formulated values as a result of an unexplained lower than desired rate of recovery (72%) of an internal standard. Chicks fed purified calcium phosphate grew better in experiment 1 (P < 0.05) and had a lower incidence of P-deficiency rickets in experiment 2 (P < 0.01) than did birds fed feed grade dicalcium phosphate. Percentage of bone ash was increased by increasing the F level in the diets in experiment 1, but not experiment 2. It was concluded that even low levels of F, such as those used in the present study, have the potential to increase bone quality.
氟化物对骨骼矿化和骨强度有不同程度的有益影响，尽管它对生长和腿部疾病有毒性作用。一些研究表明，氟补充剂会增加骨灰。本研究的目的是确定低水平的饮食氟是否会对喂食磷缺乏饮食的小鸡的骨骼强度和腿部疾病产生任何有益影响。还观察了体重和饲料效率的影响，以监测氟的毒性。将 1 日龄的直跑科布×科布肉鸡小鸡称重，随机分配到处理组，饲养在电加热的金属丝地板育雏器中，并提供水和饲料供自由采食。用 2 种不同的磷源配制磷缺乏饲料，以诱导磷佝偻病。处理 1 包含饲料级磷酸二钙，以模拟商业饮食。处理 2 包含纯化的磷酸二钙，以代表含氟量最低（~0.46mg/kg）的饮食。处理 3 和 4 使用纯化的磷酸二钙作为磷源，并分别含有 10 和 20mg/kg 的氟来自氟化钠。实验 2 还添加了 4 个处理。处理 5、6、7 和 8 使用纯化的磷酸二钙作为磷源，并分别含有 30、40、50 和 60mg/kg 的氟来自氟化钠。由于未解释的内部标准回收率（72%）低于预期，饮食中的分析氟值低于配方值。在实验 1 中，喂食纯化的磷酸钙的小鸡生长更好（P<0.05），在实验 2 中，喂食饲料级磷酸二钙的小鸡发生磷缺乏佝偻病的发病率较低（P<0.01）。在实验 1 中，随着饮食中氟水平的增加，骨灰的百分比增加，但在实验 2 中没有增加。结论是，即使是本研究中使用的低水平的氟也有可能提高骨骼质量。
