Reichel H, Koeffler H P, Norman A W
Department of Biochemistry, University of California, Riverside 92521.
Prog Clin Biol Res. 1990;332:81-97.
Perhaps, 1 alpha,25(OH)2D3 plays a role as a co-factor in the communication between lymphocytes and macrophages. A schematic representation of that proposed interaction is shown in Figure 2. (Formula: see text). For example, macrophages encounter bacteria, stimulating these cells to begin chemotaxis, phagocytosis, and killing of the microorganisms. In addition, the cells produce interleukin-1. Both interleukin-1 and bacterial antigens in the context of the Ia antigens of the macrophages activate T lymphocytes. The T lymphocytes begin to synthesize lymphokines which can further activate macrophages. Macrophages stimulated by IFN-gamma eventually synthesize 1 alpha,25(OH)2D3. Activated lymphocyte express receptors for 1 alpha,25(OH)2D3; and their lymphokine production will decrease in the presence of 1 alpha,25(OH)2D3.
或许，1α,25(OH)₂D₃在淋巴细胞与巨噬细胞之间的通讯中作为一种辅助因子发挥作用。图2展示了所提出的这种相互作用的示意图。（公式：见正文）。例如，巨噬细胞遇到细菌，刺激这些细胞开始趋化作用、吞噬作用并杀灭微生物。此外，这些细胞产生白细胞介素-1。在巨噬细胞的Ia抗原环境中，白细胞介素-1和细菌抗原都会激活T淋巴细胞。T淋巴细胞开始合成淋巴因子，进而可进一步激活巨噬细胞。受γ干扰素刺激的巨噬细胞最终合成1α,25(OH)₂D₃。活化的淋巴细胞表达1α,25(OH)₂D₃的受体；并且在1α,25(OH)₂D₃存在的情况下，它们的淋巴因子产生会减少。
