Ibrahim Jehan M, Wegdan Omar M
aDepartment of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University bMinistry of Health and Population, Cairo, Egypt.
J Egypt Public Health Assoc. 2011;86(3-4):68-72. doi: 10.1097/01.EPX.0000399136.00486.4e.
Many patients with end-stage renal disease undergoing dialysis therapy suffer from sleep disturbances. The aims of this study were to determine the prevalence of sleep disorders in patients with end-stage renal disease on maintenance dialysis and to determine the risk factors underlying these disorders.
A total of 264 patients on maintenance dialysis were enrolled in the study. Demographic, renal, and dialysis data were recorded. Using Personal Professional Interviews, we assessed the presence of the following sleep disorders: insomnia, restless leg syndrome (RLS), and obstructive sleep apnea syndrome (OSAS). Moreover, to determine the prevalence of sleep disturbances and the possible effect of demographic or clinical data on sleep, we divided our population into two groups: with and without sleep disorders.
The prevalence of sleep disorders was 61.4%. The survey revealed the presence of insomnia (57.6%), RLS (56.4%), and OSAS (21.2%). Insomnia, RLS, and OSAS were significantly associated with inadequate dialysis, hyperphosphatemia, and hypoalbuminemia. Insomnia and RLS were also significantly associated with anemia. Significant independent association was observed between insomnia and both RLS and OSAS as well as between RLS and OSAS.
The survey showed a high prevalence of sleep disruption in dialytic populations. Our data might help nephrologists to deal with patients with uremia with possible sleep disorders.
许多接受透析治疗的终末期肾病患者存在睡眠障碍。本研究的目的是确定维持性透析的终末期肾病患者睡眠障碍的患病率，并确定这些障碍的潜在危险因素。
共有264例维持性透析患者纳入本研究。记录人口统计学、肾脏和透析数据。通过个人专业访谈，我们评估了以下睡眠障碍的存在情况：失眠、不宁腿综合征（RLS）和阻塞性睡眠呼吸暂停综合征（OSAS）。此外，为了确定睡眠障碍的患病率以及人口统计学或临床数据对睡眠的可能影响，我们将研究人群分为两组：有睡眠障碍组和无睡眠障碍组。
睡眠障碍的患病率为61.4%。调查发现存在失眠（57.6%）、RLS（56.4%）和OSAS（21.2%）。失眠、RLS和OSAS与透析不充分、高磷血症和低白蛋白血症显著相关。失眠和RLS也与贫血显著相关。观察到失眠与RLS和OSAS之间以及RLS与OSAS之间存在显著的独立关联。
调查显示透析人群中睡眠中断的患病率很高。我们的数据可能有助于肾科医生处理可能存在睡眠障碍的尿毒症患者。
