Wen Ying-wu, Shen Ke-hui, Yu Wei, Guo Ying-lu, He Qun, Xi Zhi-jun
Department of Urology, Peking University First Hospital; Institute of Urology,Peking University; National Urological Cancer Center, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):565-9.
To describe early complications (within 90 days) after radical cystectomy and to analyze the associated specific risk factors.
The clinical data from 208 consecutive cases of muscle invasive bladder cancer were collected and reviewed. Potential variables predictive of early morbidity were retrospectively analyzed.
Of the 208 subjects, 160 (76.9%)developed at least 1 postoperative complication and 46 (22.2%) at least 2 complications. The most frequent complications presented were blood loss (75 cases), post-operative renal insufficiency (31 cases), and intestinal obstruction (29 cases). In univariate analysis, operative time, hypertension and preoperative creatinine level were associated with the development of complications. On multivariate analysis, operative time, preoperative creatinine level were the significant factors.
Morbidity remains high after radical cystectomy. The operative time, preoperative creatinine level and hypertension may be associated with the postoperative complications. Acknowledgement of the patients' specific risk factors and monitoring perioperative processes may incrementally reduce risks and improve outcomes of the patients.
描述根治性膀胱切除术后的早期并发症（90天内）并分析相关的特定危险因素。
收集并回顾208例连续性肌肉浸润性膀胱癌患者的临床资料。对预测早期发病的潜在变量进行回顾性分析。
208例患者中，160例（76.9%）发生至少1种术后并发症，46例（22.2%）发生至少2种并发症。最常见的并发症为失血（75例）、术后肾功能不全（31例）和肠梗阻（29例）。单因素分析显示，手术时间、高血压和术前肌酐水平与并发症的发生有关。多因素分析显示，手术时间、术前肌酐水平是显著因素。
根治性膀胱切除术后发病率仍然很高。手术时间、术前肌酐水平和高血压可能与术后并发症有关。认识患者的特定危险因素并监测围手术期过程可能会逐步降低风险并改善患者预后。
