组织病理学和基因组分级为乳腺癌提供互补的预后信息：基于公开可用数据集的研究
Histopathological and genomic grading provide complementary prognostic information in breast cancer: a study on publicly available datasets.
作者信息
Chowdhury Nilotpal
机构信息
Department of Pathology, Aarupadai Veedu Medical College, Bahour Commune Panchayat Kirumampakkam, Pondicherry 607402, India.
出版信息
Patholog Res Int. 2011;2011:890938. doi: 10.4061/2011/890938. Epub 2011 Aug 10.
The genomic grade (GG) for breast cancer is thought to be the genomic counterpart of histopathological grade (HG). The motivation behind this study was to see whether HG retains its prognostic impact even when adjusted for GG, or whether it can be replaced by the latter. Four publicly available gene expression datasets were analyzed. Kaplan-Meier curves, log rank test, and Cox regression were used to study recurrence-free survival (RFS) and distant metastasis-free survival (DMFS). HG remained a significant prognostic indicator in low GG tumors (P = 0.003 for DMFS, P< 0.001 for RFS) but not in high GG tumors. HG grade 2 tumors differed significantly from HG grade 1 tumors, underlining the prognostic role of intermediate HG tumors. Additionally, GG could stratify HG 1 as well as HG 2 tumors into distinct prognostic groups. HG and GG add independent prognostic information to each other. However, the prognostic effects of both HG and GG are time varying, with the hazard ratios of high HG and GG tumors being markedly attenuated over time.
乳腺癌的基因组分级（GG）被认为是组织病理学分级（HG）的基因组对应物。本研究的目的是探讨HG在调整GG后是否仍保留其预后影响，或者是否可以被GG取代。分析了四个公开可用的基因表达数据集。采用Kaplan-Meier曲线、对数秩检验和Cox回归来研究无复发生存期（RFS）和无远处转移生存期（DMFS）。HG在低GG肿瘤中仍然是一个显著的预后指标（DMFS的P = 0.003，RFS的P<0.001），但在高GG肿瘤中不是。HG 2级肿瘤与HG 1级肿瘤有显著差异，突显了中间HG肿瘤的预后作用。此外，GG可以将HG 1级和HG 2级肿瘤分层为不同的预后组。HG和GG相互补充独立的预后信息。然而，HG和GG的预后影响都是随时间变化的，高HG和GG肿瘤的风险比随着时间的推移显著降低。
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