Center for Bionanoengineering and the State Key Laboratory of Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
J Control Release. 2011 Oct 30;155(2):227-36. doi: 10.1016/j.jconrel.2011.07.041. Epub 2011 Aug 6.
Nanosystems with unique physical and biological properties have been extensively explored for cancer targeted intracellular delivery of small-molecular chemotherapeutic drugs to increase their therapeutic efficacies and to minimize their side effects. A large number of anticancer drugs are DNA-toxins that bind nuclear DNA or its associated enzymes to exert their cytotoxicity to cancer cells. After entering tumor cells, they need to be further delivered to the nucleus for actions. Herein, we discuss the biological barriers and summarize recent progress of nuclear drug delivery for cancer chemotherapy, emphasizing strategies that appear useful for design of vehicles capable of delivering drugs to the nucleus, particularly for in vivo applications. The existing obstacles or problems that need to be overcome before successful applications of nuclear drug delivery for cancer chemotherapy are also discussed.
纳米系统具有独特的物理和生物学特性，已被广泛探索用于癌症的靶向细胞内小分子化学治疗药物的递送来提高其治疗效果并最小化其副作用。大量的抗癌药物是 DNA 毒素，它们与核 DNA 或其相关酶结合以发挥其对癌细胞的细胞毒性。进入肿瘤细胞后，它们需要进一步递送到细胞核中进行作用。本文讨论了生物屏障，并总结了用于癌症化学治疗的核药物递送的最新进展，强调了对于设计能够将药物递送到细胞核的载体有用的策略，特别是对于体内应用。还讨论了在成功应用核药物递送至癌症化学治疗之前需要克服的现有障碍或问题。
