Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Biotechnol Adv. 2012 Sep-Oct;30(5):979-88. doi: 10.1016/j.biotechadv.2011.07.021. Epub 2011 Aug 6.
Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.
自 15 年前首次大规模重建酿酒酵母代谢网络以来，酵母代谢模型的发展迅速，已经产生了不少于 9 种不同的酵母基因组规模代谢模型。在这里，我们回顾了酵母代谢大规模数学建模的历史发展，以及这些模型在四个不同领域的应用范围和影响的不断扩大：作为代谢工程和菌株改良的指导、作为生物学解释和发现的工具、新型计算框架的应用以及进化研究。
