人源抗体治疗药物的聚集、稳定性和制剂。
Aggregation, stability, and formulation of human antibody therapeutics.
机构信息
MedImmune, Cambridge, UK.
出版信息
Adv Protein Chem Struct Biol. 2011;84:41-61. doi: 10.1016/B978-0-12-386483-3.00004-5.
Abstract
Many human monoclonal antibodies display poor biophysical properties, such as low stability and a propensity to aggregate. These unfavorable tendencies can be even more pronounced for human antibody fragments, which often require a considerable degree of optimization. In this review, we describe methods for analyzing aggregation and stability of human antibodies and antibody fragments. We also provide an overview of recent approaches to improve these properties through engineering and formulation.
摘要
许多人源单克隆抗体表现出较差的物理化学性质，例如低稳定性和易于聚集的倾向。对于人源抗体片段而言，这些不利趋势可能更为明显，因为它们通常需要相当程度的优化。在本文中，我们描述了分析人源抗体和抗体片段聚集和稳定性的方法。我们还概述了通过工程改造和制剂来改善这些性质的最新方法。
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