Department of Otolaryngology, Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
Otolaryngol Head Neck Surg. 2012 Jan;146(1):114-8. doi: 10.1177/0194599811419082. Epub 2011 Aug 16.
To investigate possible ototoxic effects of a one-time application of oxymetazoline drops in a chinchilla animal model with tympanostomy tubes. Study Design. A prospective, controlled animal study.
The Research Institute of the Montreal's Children Hospital, McGill University Health Centre.
Ventilation tubes were inserted in both ears of 12 animals. One ear was randomly assigned to receive oxymetazoline drops (0.5 mL). The contralateral ear did not receive any drops, serving as a control ear.
Distortion product otoacoustic emissions were measured bilaterally for a wide range of frequencies (between 1 and 16 kHz) before and 1 day after the application of oxymetazoline in the experimental ears. Two months later, the animals were sacrificed and all cochleae were dissected out and processed for scanning electron microscopy.
In this established chinchilla animal model, the measured distortion product otoacoustic emission amplitudes and the morphological appearance on scanning electron microscopy were similar for both control and experimental ears.
Oxymetazoline did not cause ototoxicity in a chinchilla animal model 2 months after a single application via a tympanostomy tube.
研究在鼓室置管的豚鼠动物模型中，单次使用羟甲唑啉滴鼻液是否具有耳毒性。研究设计：前瞻性、对照动物研究。
麦吉尔大学健康中心蒙特利尔儿童医院研究所。
12 只动物的双耳均插入了通气管。随机将一侧耳朵分配接受羟甲唑啉滴液（0.5 mL）。对侧耳朵未接受任何滴注，作为对照耳。
在实验耳应用羟甲唑啉前和 1 天后，对双侧进行了广泛频率（1 至 16 kHz 之间）的畸变产物耳声发射测量。2 个月后，处死动物，取出所有耳蜗并进行扫描电子显微镜处理。
在这个既定的豚鼠动物模型中，对照耳和实验耳的畸变产物耳声发射幅度和扫描电子显微镜的形态外观相似。
单次经鼓室置管应用羟甲唑啉后 2 个月，在豚鼠动物模型中未引起耳毒性。
