Dilli D, Oğuz S, Dilmen U
Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
Genet Couns. 2011;22(2):221-6.
Warfarin, which is used for anticoagulant therapy, rarely produces congenital warfarin syndrome characterized with hypoplastic nose, stippled epiphyses, and skeletal abnormalities when ingested during pregnancy. Here, we present a male infant, whose mother was treated with warfarin because of a prosthetic heart valve replacement after rheumatic heart disease, with signs of warfarin embryopathy. The mother's first pregnancy at 12 weeks gestation resulted in abortus due to warfarin toxicity. Subsequently, she delivered two healthy girls after her treatment had changed to low molecular heparin during pregnancy periods. We want to emphasize that risk-benefit ratio should be well weighed by both obstetricians and cardiologists when considering warfarin therapy for a woman at childbearing age.
用于抗凝治疗的华法林，在孕期服用时很少会导致以鼻发育不全、骨骺点状钙化和骨骼异常为特征的先天性华法林综合征。在此，我们报告一名男婴，其母亲因风湿性心脏病行人工心脏瓣膜置换术后接受华法林治疗，出现了华法林胚胎病的体征。母亲第一次怀孕在妊娠12周时因华法林毒性导致流产。随后，在孕期治疗改为低分子肝素后，她生下了两个健康的女孩。我们想强调，在考虑为育龄女性进行华法林治疗时，产科医生和心脏病专家都应充分权衡风险效益比。
