Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Cordoba University, Cordoba, Spain.
Transbound Emerg Dis. 2012 Apr;59(2):145-53. doi: 10.1111/j.1865-1682.2011.01252.x. Epub 2011 Aug 16.
Porcine reproductive and respiratory syndrome (PRRS) is considered one of the most important diseases in the swine industry. Although several studies have been carried out to elucidate the host immune response evoked against PRRS virus (PRRSV), there are several aspects that still remain unclear. The aim of this study was to determine the expression of IL-1α, IL-6 and TNF-α in the lymphoid organs (mediastinal and retropharyngeal lymph nodes and tonsil) of PRRSV-infected pigs and to determine their correlation with the expression of PRRSV antigen. Proinflammatory cytokine expression was different depending on the body compartment examined. Thus, whereas IL-1α and TNF-α were the main cytokines expressed in the mediastinal lymph node, IL-6 was the most highly expressed cytokine in the retropharyngeal lymph node, and no expression of proinflammatory cytokines was observed in the tonsil. These findings may be related to the impairment of the host immune response evoked after PRRSV infection. Therefore, lymphoid organs and proinflammatory cytokines represent an important target of study for clarifying the immunopathogenesis of PRRS.
猪繁殖与呼吸综合征（PRRS）被认为是养猪业最重要的疾病之一。尽管已经进行了多项研究来阐明针对 PRRS 病毒（PRRSV）的宿主免疫反应，但仍有几个方面尚不清楚。本研究旨在确定 PRRSV 感染猪的淋巴器官（纵隔和咽后淋巴结和扁桃体）中 IL-1α、IL-6 和 TNF-α 的表达，并确定它们与 PRRSV 抗原表达的相关性。促炎细胞因子的表达因所检查的身体部位而异。因此，虽然 IL-1α 和 TNF-α 是在纵隔淋巴结中表达的主要细胞因子，但 IL-6 是咽后淋巴结中表达最高的细胞因子，扁桃体中未观察到促炎细胞因子的表达。这些发现可能与 PRRSV 感染后宿主免疫反应受损有关。因此，淋巴器官和促炎细胞因子是阐明 PRRS 免疫发病机制的重要研究目标。
