Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
J Virol. 2011 Oct;85(20):10920-5. doi: 10.1128/JVI.05027-11. Epub 2011 Aug 17.
The mechanisms by which gammaherpesviruses maintain latency are unclear. Here we used a murine gammaherpesvirus model to show that previously uninfected B cells in immunocompetent mice can acquire virus during latency. In vivo depletion of T cells allowed viral reactivation, as measured by increased viral loads, but not enhanced transfer of virus to new cells. In the absence of both immune T cells and antibody following the transfer of latently infected cells into naïve animals, there was robust infection of new B cells. These data confirm that both T cells and antibody contribute to the control of gammaherpesvirus latency, reactivation, and spread.
γ 疱疹病毒维持潜伏的机制尚不清楚。在这里，我们使用一种鼠γ 疱疹病毒模型表明，在免疫功能正常的小鼠中，以前未被感染的 B 细胞在潜伏期间可以获得病毒。体内耗尽 T 细胞会导致病毒重新激活，这可以通过增加病毒载量来衡量，但不会增强病毒向新细胞的转移。在潜伏感染细胞转移到新生动物后既没有免疫 T 细胞也没有抗体的情况下，新的 B 细胞会受到强烈感染。这些数据证实，T 细胞和抗体都有助于控制 γ 疱疹病毒的潜伏、激活和传播。
