Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom. d.b.o'
J Clin Endocrinol Metab. 2011 Oct;96(10):E1577-87. doi: 10.1210/jc.2010-2216. Epub 2011 Aug 17.
Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe.
The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men.
Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry.
We conducted a community-based population survey in eight European centers.
Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured.
Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau.
These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger.
在欧洲，关于性激素、多个性领域功能以及与性功能相关的困扰之间的关联，仅有有限的数据可用于探索。
本研究的目的是调查血清睾丸酮（T）、雌二醇（E2）和二氢睾丸酮（DHT）与男性老龄化多中心人群研究中性功能之间的关系。
使用分层随机抽样，2838 名 40-79 岁的男性完成了欧洲男性老龄化研究-性功能问卷，并提供了血液样本进行激素测量。使用气相色谱-质谱法测量 T、E2 和 DHT。
我们在八个欧洲中心进行了一项基于社区的人群调查。
自我报告的性功能（总体性功能、与性功能相关的困扰、勃起功能障碍、自慰）。
总 T 和游离 T，但不是 E2 或 DHT，与中年和老年男性的总体性功能相关。E2 是唯一与与性功能相关的困扰相关的激素，即较高的水平与更大的困扰相关。游离 T 水平与自慰频率和勃起功能障碍在完全调整的模型中相关，即较高的 T 与较少的功能障碍和更高的频率相关。此外，总 T、性功能和勃起功能障碍之间存在 T 阈值。在 T 浓度为 8 nmol/L 或更低的情况下，T 与较差的性功能相关，而在 T 水平超过 8 nmol/L 时，这种关系趋于平稳。
这些发现表明，不同的激素机制可能调节性功能（T）与男性性行为的心理方面（E2）。此外，总体性功能存在 T 阈值，即 T 水平大于 8 nmol/L 时，T 与性功能之间的关系不会变得更强。
