载脂蛋白E缺陷小鼠的培育 - Suppr

Development of apolipoprotein E-deficient mice.

作者信息

Maeda Nobuyo

机构信息

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7525, USA.

出版信息

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1957-62. doi: 10.1161/ATVBAHA.110.220574.

DOI:10.1161/ATVBAHA.110.220574

PMID:21849705

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3286619/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf7f/3286619/03b5fab91a54/nihms-354814-f0001.jpg

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Development of apolipoprotein E-deficient mice.载脂蛋白E缺陷小鼠的培育

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State of the art: atherosclerosis in a limited edition.最新技术水平：限量版动脉粥样硬化。

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本文引用的文献

Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice.129S6/SvEvTac 和 C57BL/6J 载脂蛋白 E 基因敲除小鼠杂交群体的主动脉弓曲率和动脉粥样硬化存在重叠的数量性状位点。

Circ Res. 2010 Apr 2;106(6):1052-60. doi: 10.1161/CIRCRESAHA.109.207175. Epub 2010 Feb 4.

Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences.在缺乏假定受体结合序列的载脂蛋白B100的低密度脂蛋白受体缺陷小鼠中不存在高脂血症。

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1745-52. doi: 10.1161/ATVBAHA.108.169680. Epub 2008 Jul 10.

Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds.具有129/SvEv和C57BL/6遗传背景的载脂蛋白E缺陷小鼠的解剖学差异与动脉粥样硬化

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Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.在携带人类APOE*4而非APOE*3的小鼠中，低密度脂蛋白受体（LDLR）表达增加的有害影响。

Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):91-7. doi: 10.1161/01.ATV.0000094963.07902.FB. Epub 2003 Sep 11.

Genetic modifiers of atherosclerosis in mice.小鼠动脉粥样硬化的基因修饰因子。

Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2336-45. doi: 10.1161/01.atv.20.11.2336.

Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting.通过单一的“进出”靶向在小鼠中产生的两种不同的载脂蛋白B等位基因。

Gene. 1996 Oct 31;178(1-2):161-8. doi: 10.1016/0378-1119(96)00360-5.

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.低密度脂蛋白受体基因敲除小鼠的高胆固醇血症及其通过腺病毒介导的基因递送的逆转。

J Clin Invest. 1993 Aug;92(2):883-93. doi: 10.1172/JCI116663.

Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice.载脂蛋白A-I的缺乏与小鼠动脉粥样硬化易感性增加无关。

Arterioscler Thromb. 1993 Dec;13(12):1814-21. doi: 10.1161/01.atv.13.12.1814.

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice.饮食诱导的杂合子载脂蛋白E缺乏小鼠高胆固醇血症和动脉粥样硬化

Atherosclerosis. 1994 Nov;111(1):25-37. doi: 10.1016/0021-9150(94)90188-0.

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).遗传性高脂血症兔（WHHL兔）的连续近亲繁殖。

Atherosclerosis. 1980 Jun;36(2):261-8. doi: 10.1016/0021-9150(80)90234-8.

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Development of apolipoprotein E-deficient mice.

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