Department of Pathology and Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy.
Semin Diagn Pathol. 2011 Aug;28(3):190-201. doi: 10.1053/j.semdp.2011.03.002.
The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated.
间变性大细胞淋巴瘤（ALCL）的概念多年来发生了变化，这是因为有关这些肿瘤的起源细胞、生物学、遗传学和临床特征的新信息和新认识不断涌现。这些新信息导致了世界卫生组织专家评审员提出的当前分类。本综述的目的是介绍这些实体的细胞和组织学特征的最新信息，特别参考诊断算法。还详细描述了导致转化的遗传异常和发病机制。简要说明了 ALCL 的临床特征和新的针对性策略。
