Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.
Am J Drug Alcohol Abuse. 2011 Nov;37(6):497-508. doi: 10.3109/00952990.2011.600381. Epub 2011 Aug 18.
Cognitive impairment has been reported in drug-dependent patients under opioid maintenance treatment.
To compare cognitive functioning in healthy controls and in opioid-dependent patients treated with Buprenorphine, Heroin, or methadone maintenance.
We used the standardized test battery ART-90 to study cognitive function in patients under long-term heroin treatment (n = 20), Bup (n = 22), or Met (n = 24) maintenance treatment and healthy controls (n = 25).
Patients receiving heroin performed significantly worse than healthy controls in most domains. Heroin patients performed worse than patients in the other two treatment groups in subtests measuring psychomotor performance under stress conditions and monotony.
Although a number of limitations must be taken into account, this study provides some preliminary evidence that cognitive function may be more impaired in patients under heroin maintenance treatment than in patients receiving Bup or Met and in healthy controls.
在接受阿片类药物维持治疗的药物依赖患者中，已报道存在认知障碍。
比较健康对照组与接受丁丙诺啡、海洛因或美沙酮维持治疗的阿片类药物依赖患者的认知功能。
我们使用标准化测试组合 ART-90 来研究长期接受海洛因治疗的患者（n=20）、丁丙诺啡（n=22）或美沙酮（n=24）维持治疗组和健康对照组（n=25）的认知功能。
接受海洛因治疗的患者在大多数领域的表现明显差于健康对照组。在测量应激条件和单调环境下精神运动表现的子测试中，海洛因患者的表现比其他两组患者差。
尽管必须考虑到许多局限性，但本研究提供了一些初步证据，表明在接受海洛因维持治疗的患者中，认知功能可能比接受丁丙诺啡或美沙酮维持治疗的患者以及健康对照组更受损。
