Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Toxicol Mech Methods. 2012 Jan;22(1):60-6. doi: 10.3109/15376516.2011.596231. Epub 2011 Aug 19.
Reactivation effects of K203 and currently available oximes (obidoxime, HI-6) in combination with atropine on acetylcholinesterase activities in the brain parts of rats poisoned with tabun were studied. The activity was determined by quantitative histochemical and biochemical methods correlating between them very well. The tabun-induced changes in acetylcholinsterase activity as well as in reactivation potency of reactivators used were different in various parts of the brain. Pontomedullar area seems to be important for observed changes following tabun intoxication and its treatment. From the oximes studied, the reactivation effect of K203 was comparable with obidoxime; HI-6 was ineffective. Combination of bio- and histochemical methods allow fine differentiation among the action of different oximes following tabun poisoning.
研究了 K203 与目前可用的肟类化合物（obidoxime、HI-6）与阿托品联合对塔崩中毒大鼠脑部分乙酰胆碱酯酶活性的复活作用。通过定量组织化学和生化方法进行了活性测定，两种方法之间相关性很好。塔崩引起的乙酰胆碱酯酶活性变化以及所使用的复活剂的复活能力在大脑的不同部位是不同的。桥脑髓质区域似乎对观察到的塔崩中毒及其治疗后的变化很重要。在所研究的肟类化合物中，K203 的复活作用与 obidoxime相当；HI-6 无效。生物化学和组织化学方法的结合可以精细地区分不同肟类化合物在塔崩中毒后的作用。
