内脏利什曼病患者骨髓中不变自然杀伤 T 细胞的富集。
Enrichment of invariant natural killer T cells in the bone marrow of visceral leishmaniasis patients.
机构信息
Department of Transplant Immunology and Immunogenetics, All India Institutes of Medical Sciences, Ansari Nagar, New Delhi, India.
出版信息
Parasite Immunol. 2011 Dec;33(12):688-91. doi: 10.1111/j.1365-3024.2011.01328.x.
Abstract
Lipid antigens of Leishmania donovani like lipophosphoglycans are shown as a potent ligand for the activation of invariant natural killer T (iNKT) cells. It is reported that activation of iNKT cells augments the disease pathology in experimental visceral leishmaniasis (VL). In this study, we demonstrate the enrichment of iNKT cells in the bone marrow, one of the disease sites among patients with VL.
摘要
利什曼原虫的脂类抗原（如脂磷壁酸）被证明是一种有效的不变自然杀伤 T(iNKT)细胞激活配体。据报道，iNKT 细胞的激活会加剧实验性内脏利什曼病(VL)的疾病病理。在这项研究中，我们证明了 iNKT 细胞在骨髓中的富集，骨髓是 VL 患者的疾病部位之一。
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