Graduate Institute of Medical Science, National Defense Medical Center and Tri-Service General Hospital, Taipei.
Division of Clinical Pathology, Department of Pathology, National Defense Medical Center and Tri-Service General Hospital, Taipei.
APMIS. 2011 Sep;119(9):581-587. doi: 10.1111/j.1600-0463.2011.02790.x. Epub 2011 Jul 5.
The aim of the present study was to investigate the distribution of the Beijing strains of Mycobacterium tuberculosis (MTB) in Taipei and other Asian cities. A total of 323 MTB isolates were analyzed by spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive unit (MIRU) typing. The largest cluster of the TB isolates from Taipei was type MT11 (MIRU type 2233-2517-3533). A comparison of the MIRU type data for the Beijing strains from Taipei and previously published MIRU type data for the Beijing strains from Asian cities with major population of Chinese was analyzed. The six major Beijing MIRU types (MT01, MT02, MT08, MT11, MT21, and MT44) were found to be common in four Asian cities including Taipei, Singapore, Hong Kong, and Wuhan. Results of this study indicate that there is geographical difference in the distribution of different Beijing strains of MTB.
本研究旨在调查在台北及其他亚洲城市中结核分枝杆菌（MTB）的北京株的分布情况。通过间隔寡核苷酸分型（ spoligotyping ）和分枝杆菌间隔重复单位（MIRU）分型，对 323 株 MTB 分离株进行了分析。来自台北的结核分枝杆菌分离株中最大的聚类是 MT11 型（MIRU 型 2233-2517-3533）。比较了来自台北的北京株的 MIRU 型数据与之前发表的来自亚洲城市（主要是中国人）的北京株的 MIRU 型数据。发现六个主要的北京 MIRU 型（MT01、MT02、MT08、MT11、MT21 和 MT44）在包括台北、新加坡、香港和武汉在内的四个亚洲城市中均很常见。本研究结果表明，不同的 MTB 北京株在分布上存在地理差异。
