School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Ir Vet J. 2007 Feb 1;60(2):88-93. doi: 10.1186/2046-0481-60-2-88.
: A nine-year-old male entire Labrador was diagnosed with pituitary dependent hyperadrenocorticism. Following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and alopecia. Routine clinicopathological analyses revealed marked hypercholesterolaemia. Serum total and free thyroxine (T4) concentrations were below their respective reference ranges. Serum thyroid stimulating hormone (cTSH) concentration was within reference range. TSH and thyrotropin releasing hormone (TRH) response tests revealed adequate stimulation of total T4 in both, and cTSH in the latter test. Magnetic resonance imaging revealed a mass arising from the pituitary fossa, with suprasellar extension. A diagnosis of tertiary hypothyroidism was made. Following four weeks of levothyroxine therapy, circulating cholesterol concentration had declined, weight loss had ensued and dermatological abnormalities had improved. Euthanasia was performed four months later due to the development of neurological signs. A highly infiltrative pituitary adenoma, with effacement of the overlying hypothalamus was identified on post mortem examination. Tertiary hypothyroidism has not been previously reported in dogs.
一只 9 岁雄性全犬 Labrador 被诊断为垂体依赖性库欣氏病。经过七个月的成功米托坦治疗后，这只狗出现了明显的体重增加、皮脂溢和脱毛。常规临床病理分析显示明显的高胆固醇血症。血清总甲状腺素（T4）和游离甲状腺素（T4）浓度均低于各自的参考范围。血清促甲状腺激素（cTSH）浓度在参考范围内。TSH 和促甲状腺素释放激素（TRH）反应试验显示总 T4 和后者的 cTSH 均有充分的刺激反应。磁共振成像显示垂体窝有一个肿块，有鞍上延伸。诊断为三发性甲状腺功能减退症。在接受左旋甲状腺素治疗四周后，循环胆固醇浓度下降，体重减轻，皮肤异常得到改善。四个月后，由于出现神经症状而进行了安乐死。尸检发现高度浸润性垂体腺瘤，覆盖的下丘脑被破坏。三发性甲状腺功能减退症以前从未在狗身上报道过。
