The Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland.
Ir Vet J. 2009 May 1;62(5):334-8. doi: 10.1186/2046-0481-62-5-334.
The establishment of a single validated endoscopic laryngeal grading system for assessing recurrent laryngeal neuropathy (RLN) is desirable to facilitate direct comparisons between the findings of different clinical and research groups worldwide. The objective of this study was to assess the relationship between the Havemeyer endoscopic laryngeal grading system and histopathological changes consistent with RLN in the left cricoarytenoideus dorsalis (CAD) muscle of horses of different breeds with a full range of clinical severities of RLN, i.e., from normal endoscopic laryngeal function to complete laryngeal hemiplegia. Endoscopic grading of laryngeal function of 22 horses was performed using the Havemeyer endoscopic laryngeal grading system. A biopsy sample of the left CAD muscle was obtained from each horse, either at post mortem examination (n = 16), or during routine laryngoplasty surgery (n = 6). A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse. A significant positive correlation (rs = 0.705, p < 0.001) was found between the Havemeyer grades and sub-grades of laryngeal function and the semi-quantitative assessment of histopathological lesions consistent with RLN in the left CAD muscle. However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2. In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle.
建立一个单一的经验证的内镜喉分级系统来评估复发性喉神经病变（RLN）是理想的，以促进全球不同临床和研究小组之间的发现进行直接比较。本研究的目的是评估 Havemeyer 内镜喉分级系统与不同品种、具有各种 RLN 临床严重程度（从正常内镜喉功能到完全喉偏瘫）的马左侧环杓后肌（CAD）肌肉中与 RLN 一致的组织病理学变化之间的关系。使用 Havemeyer 内镜喉分级系统对 22 匹马的喉功能进行内镜分级。从每匹马的左侧 CAD 肌肉获得活检样本，要么在死后检查时（n = 16），要么在常规喉成形术手术期间（n = 6）。使用半定量组织病理学评分系统对每匹马左侧 CAD 肌肉中与 RLN 一致的组织病理学病变的严重程度进行分级。发现 Havemeyer 分级和喉功能亚级与左侧 CAD 肌肉中与 RLN 一致的组织病理学病变的半定量评估之间存在显著正相关（rs = 0.705，p < 0.001）。然而，获得了肌肉组织病理学评分的广泛分布，特别是在 Havemeyer 亚级 II.1、III.1 和 III.2 的马中。总之，发现 Havemeyer 内镜喉分级系统与马 CAD 肌肉中与 RLN 一致的组织病理学变化广泛相关。
