Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.
AJNR Am J Neuroradiol. 2011 Oct;32(9):1726-31. doi: 10.3174/ajnr.A2598. Epub 2011 Aug 18.
Angioplasty and stenting of the IA have been reported with high technical and clinical success rates, low complication rates and good mid-term patency rates. Different antegrade or retrograde endovascular catheter-based approaches and combinations with surgical exposure of the CCA are used. The purpose of this study was to determine safety, efficacy and mid-term clinical and radiological outcome of the stent-assisted treatment of atherosclerotic stenotic disease of the IA with special focus on the different technical approaches.
Between 1996 and 2008, 18 patients (12 men, 6 women) with symptomatic high-grade stenosis (>80%) of the IA were treated with endovascular stent placement. Their mean age was 60.4 years (range, 48-78 years). Mean angiographic and clinical follow-up was 2.7 years (range, 0.3-9.1 years). Clinical follow-up was performed by using the mRS at hospital discharge, routine follow-up controls, and a questionnaire. In 11 patients, a percutaneous approach was used. In 7 patients, the lesions were accessed retrogradely through a cervical cut-down with common carotid arteriotomy. In 2 patients, a simultaneous ipsilateral carotid endarterectomy was performed.
In all patients, primary stent placement was performed. There were 2 procedure-related transient complications (11.1%) due to cerebral embolism without permanent morbidity or mortality. During the follow-up, all patients showed improvement of the preprocedural symptoms. At the latest clinical follow-up (mean, 2.7 years), all patients showed an excellent or good outcome (mRS, 0 or 1). In 2 patients (11.1%), a secondary stent placement was needed due to a significant symptomatic in-stent stenosis.
Percutaneous and open retrograde stenting of high-grade stenosis of the IA is a viable less invasive alternatives to open bypass surgery with good midterm clinical results and patency rates.
血管成形术和支架置入术治疗颅内动脉(IA)狭窄已取得较高的技术和临床成功率,且并发症发生率低,中期通畅率较好。目前采用的技术方法包括不同的顺行或逆行血管内导管入路,以及与颈总动脉(CCA)显露相结合的方法。本研究旨在确定支架辅助治疗颅内动脉粥样硬化性狭窄的安全性、有效性和中期临床及影像学结果,重点关注不同的技术方法。
1996 年至 2008 年,18 例(12 例男性,6 例女性)有症状的颅内动脉重度狭窄(>80%)患者接受了血管内支架置入术治疗。患者平均年龄为 60.4 岁(范围,48-78 岁)。平均血管造影和临床随访时间为 2.7 年(范围,0.3-9.1 年)。通过出院时的 mRS、常规随访检查和问卷调查进行临床随访。11 例患者采用经皮入路,7 例患者通过颈侧切开行逆行入路并暴露颈总动脉进行介入治疗,2 例患者同期行同侧颈动脉内膜切除术。
所有患者均成功实施了一期支架置入术。2 例(11.1%)患者发生与手术相关的短暂性并发症(脑栓塞),但无永久性并发症或死亡。随访期间,所有患者的术前症状均得到改善。末次临床随访(平均 2.7 年)时,所有患者均取得了良好或极好的结局(mRS 评分 0 或 1)。2 例(11.1%)患者因支架内显著症状性狭窄需要再次支架置入。
经皮和开放逆行支架置入术治疗颅内动脉重度狭窄是一种可行的微创替代方法,与开放旁路手术相比,具有良好的中期临床结果和通畅率。