JC 病毒抗体和病毒血症可预测人类免疫缺陷病毒 1 感染个体的进行性多灶性白质脑病。
JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.
机构信息
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Clin Infect Dis. 2011 Oct;53(7):711-5. doi: 10.1093/cid/cir507. Epub 2011 Aug 18.
Abstract
We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis.
摘要
我们研究了前驱期约翰·坎宁安病毒（JCV）抗体和病毒血症是否可预测 83 例进行性多灶性白质脑病（PML）病例和 240 例人类免疫缺陷病毒（HIV）疾病匹配对照者中的 PML。JCV 病毒血症不能预测 PML，但一些患者在诊断前 6 个月显示出更高的抗 JCV 免疫球蛋白 G（IgG）反应。
相似文献
1
JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.JC 病毒抗体和病毒血症可预测人类免疫缺陷病毒 1 感染个体的进行性多灶性白质脑病。
Clin Infect Dis. 2011 Oct;53(7):711-5. doi: 10.1093/cid/cir507. Epub 2011 Aug 18.
2
Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients.人类免疫缺陷病毒感染患者进行性多灶性白质脑病的诊断前病毒学标志物研究。
J Med Virol. 2009 Jul;81(7):1140-50. doi: 10.1002/jmv.21493.
3
Diagnostic and Prognostic Value of JC Virus DNA in Plasma in Progressive Multifocal Leukoencephalopathy.JC 病毒 DNA 在进展性多灶性白质脑病血浆中的诊断和预后价值。
Clin Infect Dis. 2018 Jun 18;67(1):65-72. doi: 10.1093/cid/ciy030.
4
JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.1型人类免疫缺陷病毒合并进行性多灶性白质脑病患者的JC病毒特异性免疫反应
J Virol. 2009 May;83(9):4404-11. doi: 10.1128/JVI.02657-08. Epub 2009 Feb 11.
5
A second-generation ELISA (STRATIFY JCV™ DxSelect™) for detection of JC virus antibodies in human serum and plasma to support progressive multifocal leukoencephalopathy risk stratification.用于检测人血清和血浆中 JC 病毒抗体的第二代 ELISA（STRATIFY JCV™ DxSelect™），以支持进行进行性多灶性白质脑病的风险分层。
J Clin Virol. 2013 Jun;57(2):141-6. doi: 10.1016/j.jcv.2013.02.002. Epub 2013 Mar 5.
6
The effect of plasma exchange on serum anti-JC virus antibodies.血浆置换对血清抗 JC 病毒抗体的影响。
Mult Scler. 2013 Jun;19(7):912-9. doi: 10.1177/1352458512467502. Epub 2012 Dec 11.
7
Brief Report: Decreased JC Virus-Specific Antibody-Dependent Cellular Cytotoxicity in HIV-Seropositive PML Survivors.简报：HIV 血清阳性 PML 幸存者中 J 型多瘤病毒特异性抗体依赖细胞细胞毒性降低。
J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):220-224. doi: 10.1097/QAI.0000000000002105.
8
Longitudinal JCV serology in multiple sclerosis patients preceding natalizumab-associated progressive multifocal leukoencephalopathy.在那他珠单抗相关的进行性多灶性白质脑病之前，对多发性硬化症患者进行的纵向JCV血清学研究。
Mult Scler. 2015 Oct;21(12):1600-3. doi: 10.1177/1352458514567728. Epub 2015 Feb 6.
9
Prognostic significance of JC virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy.HIV 相关进行性多灶性白质脑病患者脑脊液中 JC 病毒 DNA 水平的预后意义
Clin Infect Dis. 2005 Mar 1;40(5):738-44. doi: 10.1086/427698. Epub 2005 Feb 1.
10
Preparation of monoclonal antibodies to JC virus and their use in the diagnosis of progressive multifocal leucoencephalopathy.JC病毒单克隆抗体的制备及其在进行性多灶性白质脑病诊断中的应用。
J Med Virol. 1991 Jun;34(2):127-31. doi: 10.1002/jmv.1890340211.
引用本文的文献
1
JC Polyomavirus Infection: A Narrative Review.JC多瘤病毒感染：一篇叙述性综述
Infect Dis Ther. 2025 Sep;14(9):2007-2028. doi: 10.1007/s40121-025-01199-y. Epub 2025 Jul 27.
2
Progressive multifocal leukoencephalopathy after durvalumab treatment for acute myeloid leukemia: A consequence of an immune reconstitution inflammatory syndrome?度伐利尤单抗治疗急性髓系白血病后发生进行性多灶性白质脑病：免疫重建炎症综合征的后果？
EJHaem. 2022 May 29;3(3):958-961. doi: 10.1002/jha2.485. eCollection 2022 Aug.
3
Understanding progressive multifocal leukoencephalopathy: links between milky-way appearance and mismatch T2/FLAIR.了解进行性多灶性白质脑病：银河外观与 T2/FLAIR 不匹配之间的联系。
Neuroradiol J. 2021 Dec;34(6):646-655. doi: 10.1177/19714009211019374. Epub 2021 May 28.
4
Brief Report: Decreased JC Virus-Specific Antibody-Dependent Cellular Cytotoxicity in HIV-Seropositive PML Survivors.简报：HIV 血清阳性 PML 幸存者中 J 型多瘤病毒特异性抗体依赖细胞细胞毒性降低。
J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):220-224. doi: 10.1097/QAI.0000000000002105.
5
Progressive Multifocal Leukoencephalopathy in Primary Immunodeficiencies.原发性免疫缺陷病中的进行性多灶性白质脑病。
J Clin Immunol. 2019 Jan;39(1):55-64. doi: 10.1007/s10875-018-0578-8. Epub 2018 Dec 14.
6
JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor during the follow-up of multiple sclerosis patients treated with natalizumab.在接受那他珠单抗治疗的多发性硬化症患者随访期间，JC多瘤病毒的表达及其SF2/ASF抑制因子的钟形调节。
J Neurovirol. 2017 Apr;23(2):226-238. doi: 10.1007/s13365-016-0492-x. Epub 2016 Nov 3.
7
Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.多瘤病毒JC及进行性多灶性白质脑病的诊断检测
Rev Med Virol. 2016 Mar;26(2):102-14. doi: 10.1002/rmv.1866. Epub 2015 Dec 14.
8
BK virus capsid antibodies are associated with protection against subsequent development of PML in HIV-infected patients.BK病毒衣壳抗体与HIV感染患者预防随后发生进行性多灶性白质脑病相关。
Virology. 2015 Nov;485:467-72. doi: 10.1016/j.virol.2015.08.022. Epub 2015 Sep 7.
9
Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate.一名接受富马酸二甲酯治疗的银屑病患者出现进行性神经功能障碍。
Ann Neurol. 2015 Oct;78(4):501-14. doi: 10.1002/ana.24471. Epub 2015 Jul 31.
10
JC polyomavirus reactivation is common following allogeneic stem cell transplantation and its preemptive detection may prevent lethal complications.在异基因干细胞移植后，JC多瘤病毒再激活很常见，其抢先检测可能预防致命并发症。
Bone Marrow Transplant. 2015 Jul;50(7):984-91. doi: 10.1038/bmt.2015.68. Epub 2015 Apr 13.
本文引用的文献
1
Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project.利妥昔单抗、那他珠单抗和依法珠单抗治疗患者中与单克隆抗体相关的进行性多灶性白质脑病：药物不良事件和报告研究（RADAR）项目的综述
Lancet Oncol. 2009 Aug;10(8):816-24. doi: 10.1016/S1470-2045(09)70161-5.
2
Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients.人类免疫缺陷病毒感染患者进行性多灶性白质脑病的诊断前病毒学标志物研究。
J Med Virol. 2009 Jul;81(7):1140-50. doi: 10.1002/jmv.21493.
3
Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors.400名健康献血者中多瘤病毒BK和JC感染及复制的患病率
J Infect Dis. 2009 Mar 15;199(6):837-46. doi: 10.1086/597126.
4
Prospective study of JC virus seroreactivity and the development of colorectal cancers and adenomas.JC病毒血清反应性与结直肠癌及腺瘤发生的前瞻性研究
Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1515-23. doi: 10.1158/1055-9965.EPI-08-1119. Epub 2009 Apr 21.
5
Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study.瑞士HIV队列研究20年期间进行性多灶性白质脑病的发病率及转归
Clin Infect Dis. 2009 May 15;48(10):1459-66. doi: 10.1086/598335.
6
JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.1型人类免疫缺陷病毒合并进行性多灶性白质脑病患者的JC病毒特异性免疫反应
J Virol. 2009 May;83(9):4404-11. doi: 10.1128/JVI.02657-08. Epub 2009 Feb 11.
7
Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid.用于检测尿液和脑脊液中JC病毒和BK病毒核苷酸序列的聚合酶链反应- Southern杂交法与定量实时聚合酶链反应的比较
J Virol Methods. 2004 Nov;121(2):217-21. doi: 10.1016/j.jviromet.2004.06.021.
8
Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40.基于人群的人类多瘤病毒BKV和JCV以及猿猴多瘤病毒SV40抗体研究。
J Med Virol. 2003 Sep;71(1):115-23. doi: 10.1002/jmv.10450.
9
Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions.获得性免疫缺陷综合征中的进行性多灶性白质脑病：解释该疾病相对于其他免疫抑制状况的高发病率和不成比例的发病频率。
J Neurovirol. 2003;9 Suppl 1:38-41. doi: 10.1080/13550280390195261.
10
HIV-1-infected patients with focal neurologic signs: diagnostic role of PCR for Toxoplasma gondii, Epstein-Barr virus, and JC virus.伴有局灶性神经体征的HIV-1感染患者：PCR检测弓形虫、EB病毒和JC病毒的诊断作用
Clin Microbiol Infect. 1998;4(10):577-584. doi: 10.1111/j.1469-0691.1998.tb00040.x.
Zotero 插件