Pariser Marlene S, Berdoulay Paul
Animal Allergy and Dermatology, North Chesapeake, VA, USA.
J Am Anim Hosp Assoc. 2011 Sep-Oct;47(5):375-6. doi: 10.5326/JAAHA-MS-5565. Epub 2011 Aug 18.
A 3 yr old, 70 kg (154 lbs) female spayed Great Dane developed gingival hyperplasia after treatment of systemic hypertension with amlodipine 7.5 mg q 12 hr for 16 mo. Physical examination was unremarkable except for systemic hypertension and severe gingival hyperplasia. Amlodipine was replaced with hydralazine (0.72 mg/kg [0.32 mg/lb]). Nine months later, gingival hyperplasia was nearly resolved and hypertension was well controlled. Calcium channel blockers such as amlodipine are a rare cause of gingival hyperplasia in the canine patient. Recognition of this side effect is important because a full recovery can be achieved when the offending agent is removed.
一只3岁、体重70公斤（154磅）的雌性绝育大丹犬，在用氨氯地平7.5毫克，每12小时一次，治疗全身性高血压16个月后出现牙龈增生。体格检查除全身性高血压和严重牙龈增生外无异常。氨氯地平被肼屈嗪（0.72毫克/千克[0.32毫克/磅]）替代。9个月后，牙龈增生几乎消退，高血压得到良好控制。像氨氯地平这样的钙通道阻滞剂是犬类患者牙龈增生的罕见原因。认识到这种副作用很重要，因为去除致病药物后可以实现完全康复。
