Stanford Stroke Center, 780 Welch Road, Suite 205, Palo Alto, CA 94304, USA.
Stroke. 2011 Sep;42(9):2645-50. doi: 10.1161/STROKEAHA.111.618850. Epub 2011 Aug 18.
The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of acute and restorative stroke therapies. Summary of Review- At the STAIR VII recommendations for strategies to maximize the use of intravenous thrombolytics through targeting public education, and the refinement of current treatment exclusion criteria were proposed. Increased utilization of mechanical devices for intra-arterial recanalization can be achieved by obtaining more definitive evidence of efficacy in randomized clinical trials, identification of patient characteristics associated with treatment efficacy, optimization of technical approaches, clarification of effective time windows, and development of approaches to limit complications. Neuroprotective strategies remain viable; recommendations for further study of these agents include an emphasis on rapid administration, consideration of the systemic effects of ischemic stroke, prevention of complications associated with early reperfusion, a focus on agents with multiple mechanisms of action, and consideration of possible interactions between neuroprotective and thrombolytic therapies.
Extending intravenous thrombolysis to a broader patient population, clarifying the risk and benefits of intra-arterial reperfusion therapies, and further development of neuroprotective therapies were the key recommendations from STAIR VII.
卒中治疗学术产业圆桌会议（STAIR）的目标是推进急性和恢复性卒中治疗的发展。综述摘要-在 STAIR VII 会议上，提出了通过针对公众教育和完善当前治疗排除标准来最大限度地利用静脉溶栓的策略建议。通过在随机临床试验中获得更明确的疗效证据、确定与治疗效果相关的患者特征、优化技术方法、澄清有效的时间窗以及开发限制并发症的方法，可以实现更多机械装置用于动脉内再通。神经保护策略仍然可行；进一步研究这些药物的建议包括强调快速给药、考虑缺血性卒中的全身影响、预防与早期再灌注相关的并发症、关注具有多种作用机制的药物以及考虑神经保护和溶栓治疗之间的可能相互作用。
STAIR VII 的主要建议是将静脉溶栓扩展到更广泛的患者群体、阐明动脉内再灌注治疗的风险和益处，并进一步开发神经保护治疗。
